Sam Jones

My research focuses on developing CRISPR-based genetic therapies for inherited cardiomyopathies. Much of my work focuses on developing therapies which address the underlying molecular and genetic mechanisms of hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM). My aim is to develop a cure to permanently alter the genetic code, in order to restore healthy contractility, calcium handling and energetics within the heart muscle. To measure progress towards these goals, I use induced pluripotent stem cell derived cardiomyocytes (beating heart muscle cells in a dish derived from stem cells) as a disease model. 

Prior to joining CureHeart, I completed an Integrated Masters in Biology at the University of Oxford. During my research project, I worked on developing disease models to improve our understanding of MYBPC3 variants in HCM.