Eric Wei

eric wei
Associate Physician and Instructor
Division of Cardiovascular Medicine, Brigham and Women’s Hospital, Harvard Medical School

Eric Wei is a cardiologist at Brigham and Women’s Hospital and an Instructor at Harvard Medical School. He conducts research in the laboratory of Professors Christine and Jonathan Seidman, focusing on the genetic and cellular mechanisms underlying inherited heart disease.

Dr. Wei earned his PhD at Duke University under the mentorship of Dr. Geoffrey Pitt, where he identified a novel role for the non-canonical fibroblast growth factor FGF13 in regulating caveolae structure and hypertrophic signaling in cardiomyocytes.

His current research focuses on understanding how pathogenic genetic variants drive cardiac hypertrophy and arrhythmias in conditions such as hypertrophic and dilated cardiomyopathy. Using advanced 3D microscopy and computational image analysis, his work has uncovered previously unrecognized, genotype-specific patterns of cellular remodeling in heart muscle, helping explain why patients with the same clinical diagnosis can experience different disease trajectories and risks. His long-term goal is to translate these insights into improved risk stratification and more targeted therapies for patients and families affected by inherited heart disease.

Publications:    

  1. Deep-learning analysis of 3D microarchitectural remodeling in hypertrophic cardiomyopathy. Wei E, Beyer M, et al. (2026). Science.

  2. Unmasking the hidden genetic burden of heart failure: A call to action. Wei E, et al. (2025). JACC: Heart Failure.

  3. Inducible Fgf13 ablation enhances caveolae-mediated cardioprotection during cardiac pressure overload. Wei E et al. (2017). Proceedings of the National Academy of Sciences USA.
  4. Fibroblast Growth Factor Homologous Factors Modulate Cardiac Calcium Channels. Hennessey J and Wei E et al. (2013). Circulation Research.
  5. Fibroblast growth factor homologous factors in the heart: a potential locus for cardiac arrhythmias. Wei E et al. (2012). Trends in Cardiovascular Medicine.