Ying-Jie Wang

Ying-Jie received his training as a platelet biologist at Newcastle University and the University of Birmingham. He subsequently studied the lymphatic system and immune cell trafficking at the Weatherall Institute of Molecular Medicine (WIMM) at the University of Oxford. Later, he joined Professor Hugh Watkins' Inherited Heart Muscle Research Group on a cardio-immunology project. His research focuses on understanding the role of non-cardiomyocytes, such as immune, stromal, and endothelial cells, in progressive adverse remodeling in hypertrophic cardiomyopathy (HCM). He employs animal models, human samples, and multi-omics studies to identify targets for developing therapies that modulate cardiac fibrosis.

Publications:    

1. Regulatory T cells attenuate chronic inflammation and cardiac fibrosis in hypertrophic cardiomyopathy. Wang YJ et al. (2024) Submitted to Science Translational Medicine
2. TNF-derived peptides inhibit tumour growth and metastasis through cytolytic effects on tumour lymphatics. Lu W et al. (2019) Clinical Experimental Immunology
3. Megakaryocyte-specific deletion of the protein-tyrosine phosphatases Shp1 and Shp2 causes abnormal megakaryocyte development, platelet production, and function. Mazharian A et al. (2013) Blood
4. Dominant role of the protein-tyrosine phosphatase CD148 in regulating platelet activation relative to protein-tyrosine phosphatase-1B. Mori J et al. (2012) Arteriosclerosis Thrombosis and Vascular Biology
5. Mice lacking the ITIM-containing receptor G6b-B exhibit macrothrombocytopenia and aberrant platelet function. Mazharian A and Wang et al. (2012) Science Signaling