In this proof-of concept study, CureHeart PI Eric Olson and his team identify an adenine base editor and single-guide RNA system which can efficiently correct the genetic alteration which leads to hypertrophic cardiomyopathy (HCM) without the need for complex viral delivery. This exciting study demonstrates the potential of base editing to treat inherited cardiac diseases, and forms the basis of much of CureHeart's work over the coming years.
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